Around the world, almost three million newborns die in their first month of life every year. Ninety-nine percent of these deaths take place in developing countries. Yet, most can be prevented with proven and cost-effective interventions such as delivering Home-Based Newborn Care (HBNC) packages to vulnerable populations at the community level. These interventions are straightforward, such as home visits during the first 28 days of life, using sterile blades to cut umbilical cords, teaching mothers the importance of immediate breastfeeding, treating infections, and keeping newborn babies warm. Here we profile the group in rural India that pioneered HBNC packages 15 years ago as a way to reduce neonatal mortality rates. Its work has since been adapted by additional humanitarian organizations and governments and spread throughout India and to countries in Africa and South Asia.